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What Is BHRT Made From? A Comprehensive Guide to Bioidentical Hormone Replacement Therapy Ingredients


Published September 3, 2025

Bioidentical Hormone Replacement Therapy (BHRT) has gained significant attention as a natural alternative to traditional hormone replacement therapies. Many individuals seek BHRT to alleviate symptoms of hormonal imbalances caused by aging, menopause, and other health conditions. But what exactly is BHRT made from? Understanding the sources and composition of these hormones can help patients make informed decisions about their treatment.

We will review the origins, extraction processes, and composition of bioidentical hormones and how they compare to synthetic hormones.

What Are Bioidentical Hormones?

Bioidentical hormones are compounds with the same molecular structure as the hormones naturally produced by the human body. This structural similarity allows them to be effectively utilized by the body without causing the adverse effects associated with some synthetic hormones.

The primary bioidentical hormones used in BHRT include:

Natural Sources of Bioidentical Hormones

Unlike synthetic hormones, which are typically derived from animal sources or chemically synthesized in a lab, bioidentical hormones are derived from natural plant sources. The most common sources include:

Soybeans

Soy contains phytoestrogens, plant-based compounds that mimic estrogenic activity in the body. The key component derived from soy is diosgenin, which serves as a precursor for synthesizing bioidentical estrogens and progesterone.

Wild Yams (Dioscorea Villosa)

Wild yams are another major source of diosgenin, which can be converted into progesterone, estrogen, and other steroid hormones in a laboratory setting. However, the body cannot directly convert wild yam extracts into usable hormones; they must undergo chemical transformation in a compounding pharmacy.

The Process of Extracting Bioidentical Hormones

The process of creating bioidentical hormones involves several steps:

  1. Extraction: Diosgenin is extracted from soybeans or wild yams.
  2. Conversion: The extracted diosgenin undergoes a series of chemical reactions in a lab to transform it into bioidentical hormones.
  3. Purification: The hormones are purified and tested to ensure they are structurally identical to human hormones.
  4. Formulation: The final bioidentical hormones are compounded into various delivery methods, such as creams, gels, capsules, injections, or sublingual tablets.

How Bioidentical Hormones Differ from Synthetic Hormones

Traditional hormone replacement therapy (HRT) often uses synthetic hormones, which can have different molecular structures from the hormones naturally produced by the body. For example:

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Because bioidentical hormones match human hormones structurally, they are believed to have fewer side effects and better efficacy in restoring hormonal balance.

Forms of Identical Hormones and Their Uses

Bioidentical hormones can be customized to meet individual needs and are available in various forms:

Are Bioidentical Hormones Safe?

One key advantage of BHRT is that it can be customized to match an individual patient’s hormonal profile. While some research suggests that bioidentical hormones may carry fewer risks than synthetic alternatives, all hormone therapies should be used under medical supervision. Factors such as dosage, method of administration, and individual health conditions must be considered to ensure safety and effectiveness.

BHRT is made from plant-derived compounds, primarily from soybeans and wild yams. These sources provide diosgenin, which is converted into bioidentical hormones through laboratory processes. Unlike synthetic hormones, bioidentical hormones have an identical molecular structure to human hormones, potentially offering better compatibility and fewer side effects.

If you’re considering BHRT, consult a knowledgeable BodyLogicMD practitioner to determine the best approach for your unique needs. Understanding what goes into your therapy is the first step toward achieving optimal hormonal balance and overall well-being.

Is BHRT Right for Me?

About BodyLogicMD

BodyLogicMD is a leading network of wellness centers specializing in personalized treatments to help clients achieve optimal health and vitality. With a focus on bioidentical hormone replacement therapy (BHRT), weight loss solutions, and integrative medicine, BodyLogicMD works with patients to create individualized plans that address unique health needs. The BodyLogicMD team of experts is dedicated to empowering individuals to feel youthful, energized, and balanced, all while providing compassionate, customized care.

The post What Is BHRT Made From? A Comprehensive Guide to Bioidentical Hormone Replacement Therapy Ingredients appeared first on BodyLogicMD.

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What our clients say about us

*Results not typical. Always seek the advice of your physician or qualified healthcare provider before making any changes to your healthcare regimen. See our Full Disclaimer.
  • My wife and I starting coming to BodyLogicMD a few years ago as were both feeling the effects of our aging. She was pre-menopausal with slight weight gain and night sweats and low energy and I was suffering from very low testosterone as most men over 40 do and had low energy. My wife read about hormone treatment in a book by Susanne Somers and we searched out doctors in Atlanta that offered it and found BodylogicMD. After being on our treatment programs for about 90 days we both felt great and our symptoms went away and we have maintained...Read More
  • "At 44 I was tired of feeling tired. I wasn't sleeping through the night, waking up with the sweats and just not able to turn my brain off. During the day, I had no energy. The 3 pm slump would hit me like a ton of bricks everyday - no matter how well I had slept the night before. My libido was pretty much zilch and I was seriously moody. Worst of all, don't tell my husband the no libido wasn't the worst, I couldn't lose weight to save my life. After hearing about BodyLogicMD, I decided that something needed...Read More

  • "I was unable to find a provider who specializes in female hormones through my OBGYN – they just give you the pill which I didn’t want. And, my endocrinologist fell short in this area. Then I found BodyLogicMD of Atlanta and Dr. Karen Weldon. At my first appointment, the office staff was great, and Dr. Weldon was very thorough in reviewing my lab results. During the course of my treatment, Dr. Weldon has been very quick in responding to all my questions via email which is very convenient. I can write to her when an issue is happening and...Read More

  • "Dr. Donohue has been treating me for several years now and the change in my health has been incredible.  I no longer have that “foggy” feeling, my thoughts are now clear and concise.  I have more energy and look healthier than I have ever looked before, and my friends and family have noticed and commented favorably.  With the boost in energy I’m able to exercise more and that has resulted in a better looking body and a lower number on the scale!  I completely trust Dr. Donohue, he’s knowledgeable and takes the time to explain things, is compassionate and is...Read More
  • "My husband I have been Dr. Donohue’ patients for the past several years and we can honestly say it has been a life changing experience for us….., as we grow “younger”, we have been faced with many age related deteriorations physically and mentally…., Dr. Donohue’ precise HRT therapy and supplements have made us feel and look as young as we feel at our hearts…, plus I love the fact Dr. Donohue is prompt and we never have to wait more than 5 mins!!!!!!!! The staff at his office is wonderful as well; professional, friendly and very caring; we are just...Read More

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